Lynne Matallana, author of The Complete Idiot’s Guide to Fibromyalgia, explains that “Often when a healthcare professional suggests an antidepressant to treat the symptoms of Fibromyalgia, the patient gets concerned that the physician thinks that they are just depressed. In reality, antidepressants are often prescribed to treat multiple symptoms, including pain and sleep disturbances. “If an antidepressant is prescribed for you, don’t take offense, instead talk to your healthcare professional and find out why he or she is suggesting that you take an antidepressant.” She further explains that “In the 1970’s, the initial research on Fibromyalgia reported low serotonin levels in people with this disorder. Therefore, the original pharmacological approaches (that are still being used today) for treating Fibromyalgia included amitriptyline, cyclobenzaprine, and other tricyclic antidepressants. These drugs tend to increase serotonin throughout the central nervous system. “Selective serotonin reuptake inhibitors such as Prozac, Zoloft, Paxil, Effexor, Serzone, and Celexa are used to improve mood and decrease pain. “The antidepressants venlafaxine and nefazodone are medications that inhibit the reuptake of both serotonin and norepinephrine. Studies have shown that both medications have helped patients with sleep, mood, and fatigue complaints.” Note: The information provided here is not intended to diagnose, treat, cure, mitigate, or prevent any disease. Be sure to consult your physician for medical advice.