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Are NMN and NR Effective Supplements for Depression?

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To understand if NMN and NR may be effective supplements for depression, you need to understand the cause and effect of a biochemical chain of events. The four principal actors in this chain are:

  1. Depression, a persistent mood disorder with physiological effects
  2. Sirtuins, a regulator of various biological mechanisms, including some physiological effects of depression
  3. NAD+ (nicotinamide adenine dinucleotide), a coenzyme found in all living cells that’s necessary for life
  4. NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside), two precursors (boosters) of NAD+

After taking a look at deleterious effects of depression, I’ll explain the interplay between it, sirtuins, NAD+ and finally the last link in this chain, NMN/NR…

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