Are we on the threshold of a new theory of disease? Toxicant-induced loss of tolerance & its relationship to addiction & abdiction – Chronic Fatigue Syndrome and fibromyalgia related research

‘Toxicant-induced loss of tolerance’ (or TILT) describes a

two-step disease process in which (1) certain chemical

exposures, e.g., indoor air contaminants, chemical spills, or

pesticide applications, cause certain susceptible persons to

lose their prior natural tolerance for common chemicals,

foods, and drugs (initiation); (2) subsequently, previously

tolerated exposures trigger symptoms. Responses may manifest

as addictive or abdictive (avoidant) behaviors.

In some

affected individuals, overlapping responses to common

chemical, food, and drug exposures, as well as habituation to

recurrent exposures, may hide (mask) responses to particular

triggers. Accumulating evidence suggests that this disease

process might underlie a broad array of medical illnesses

including chronic fatigue, fibromyalgia, migraine headaches,

depression, asthma, the unexplained illnesses of Gulf War

veterans, multiple chemical sensitivity, and attention deficit


Miller CS

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