- Prohealth - https://www.prohealth.com -

Autoantibody pain

By A. Goebel
 
Abstract
 
As autoantibodies bind to target tissues, Fc-region dependent inflammation can induce pain via mediators exciting nociceptors. But recently another possibility has emerged, where autoantibody binding to nociceptors can directly cause pain, without inflammation. This is thought to occur as a result of Fab-region mediated modification of nerve transduction, transmission, or neuropeptide release.
 
In three conditions, complex regional pain syndrome, anti-voltage gated potassium channel complex autoimmunity, and chronic fatigue syndrome, all associated with no or only little inflammation, initial laboratory-, and trial-results have suggested a potential role for autoantibody-mediated mechanisms.
 
More research assessing the pathogenic roles of autoantibodies in these and other chronic pain conditions is required. The concept of autoantibody-mediated pain offers hope for the development of novel therapies for currently intractable pains.

Copyright © 2016. Published by Elsevier B.V.
 
Source: Goebel A. Autoantibody pain. Autoimmun Rev. [1] 2016 Feb 12. pii: S1568-9972(16)30037-4. doi: 10.1016/j.autrev.2016.02.011. [Epub ahead of print]