Borrelia burgdorferi reactivity in patients with severe persist fatigue who are from a region .. Lyme disease is endemic

Borrelia burgdorferi is the pathogen that causes Lyme disease.

Patients frequently experience fatigue and malaise that can

persist after antibiotic treatment. This study examined

serological reactivity to B. burgdorferi in patients with

chronic fatigue who were from a region in which Lyme disease

is endemic. Blood and CSF were collected from patients without

a history of infection due to B. burgdorferi (n = 12) and

patients with persistent fatigue after antibiotic treatment of

Lyme disease (n = 13). Serum and CSF were examined by ELISA

for antibodies to B. burgdorferi, and routine studies of CSF

were done. In the first group, one patient (8%) was

seropositive; no patients had detectable antibodies in CSF. In

the second group, nine patients (69%) were seropositive or

borderline seropositive; seven (54%) had detectable antibodies

in CSF. Unexplained abnormalities in CSF were noted in 42% and

31% of patients in each group, respectively. In this study

positive serologies for Lyme disease were not found at a

higher than expected rate for patients from a region of Lyme

disease endemicity who had idiopathic chronic fatigue.

Fatigued patients did show a surprisingly high rate of

unexplained minor CSF abnormalities suggestive of CNS or

meningeal dysfunction.

Coyle PK, Krupp LB, Doscher C, Amin K

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