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Borreliacidal OspC antibody response of canines with Lyme disease differs significantly from that of humans with Lyme disease.

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Abstract

Humans reliably produce high concentrations of borreliacidal OspC antibodies specific for the seven C-terminal amino acids shortly after infection with Borrelia burgdorferi. We show that dogs also produce OspC borreliacidal antibodies but that their frequencies, intensities, and antigenicities differ significantly. The findings therefore confirm a major difference between the borreliacidal antibody responses of humans and canines with
Lyme disease.

Clin Vaccine Immunol. 2007 May;14(5):635-7. Epub 2007 Mar 7. Clinical Trial

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