Journal: Pharmacopsychiatry. 2006 Jul;39(4):152-4. Authors: Schonfeldt-Lecuona C, Connemann BJ, Wolf RC, Braun M, Freudenmann RW. Affiliation: University of Ulm, Department of Psychiatry, Leimgrubenweg 12 – 14, 89075 Ulm, Germany. NLM Citation: PMID: 16871471 While psychoeducational strategies and general support are always indicated for the treatment of chronic fatigue syndrome (CFS), pharmacological strategies are yet not well established. Antidepressants such as selective serotonin re-uptake inhibitors have been shown to influence positively symptoms and immunological parameters. However, a considerable part of CFS patients do not satisfactorily respond to them. Bupropion, a centrally acting catecholamine-transporter blocker without classic psycho-analeptic properties, shows theoretical potential to improve fatigue symptoms. In the reported case paroxetine was augmented with bupropion at high dosage, a strategy which consecutively led to a rapid relief of CFS-symptoms.