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Carnitine May Improve Neuronal Function in Lyme Disease

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Editor’s Note: The results of this study suggest that carnitine supplementation, which plays a crucial role in metabolism, energy and inflammation, may help to prevent neuronal dysfunction and loss of brain functioning in people with Lyme disease.
 
Abstract
 
BACKGROUND:
Lyme borreliosis (LB) is a serious infectious disease. Carnitine plays a crucial role in metabolism and inflammatory responses. Carnitine may be important in improving neuronal dysfunction and loss of neurons.
 
AIM:
To evaluate serum carnitine concentration in adult patients with various clinical types of LB.
 
MATERIAL/METHODS:
Groups: 1) patients with erythema migrans (EM, n=16), 2) neuroborreliosis (NB, n=10), 3) post-Lyme disease (PLD, n=22) and healthy controls (HC, n=32). Total (TC) and free (FC) carnitine were determined with the spectrophotometric method.
 
RESULTS:
TC levels (44.9±10.4, 28.0±8.4, 35.9±15.6 ?mol/L) in the EM, NB and PLD patients were lower than in HC (54.0±11.4 ?mol/L), p < 0.001. FC levels (32.7±7.7, 23.6±6.8, 26.3±11.2 ?mol/L) in the EM, NB and PLD patients were lower than in HC (40.5±7.6 ?mol/L), p < 0.001. AC levels (12.2±5.2, 4.4±2.6, 9.6±7.4 ?mol/L) in the EM, NB and PLD patients were lower in the NB and PLD patients than in HC (13.5±8.40 ?mol/L), p <0.001. AC/FC ratio was 0.31±0.14, 0.18±0.09, 0.39±0.33 in the EM, NB and PLD patients.
 
CONCLUSIONS:
LB patients exhibit a significant decrease of their serum carnitine concentrations. The largest changes were in the NB and PLD patients. To prevent late complications of the disease a possibility of early supplementation with carnitine should be considered. Further studies are required to explain the pathophysiological significance of our findings.
 
Source: By Kepka A1, Pancewicz SA2, Janas RM1, Swierzbinska R2. Serum carnitine concentration is decreased in patients with Lyme borreliosis. Postepy Hig Med Dosw (Online). 2016 Mar 4;70:180-5. doi: 10.5604/17322693.1196388.
 

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