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Editor’s Note: The results of this study suggest that carnitine supplementation, which plays a crucial role in metabolism, energy and inflammation, may help to prevent neuronal dysfunction and loss of brain functioning in people with Lyme disease.
Lyme borreliosis (LB) is a serious infectious disease. Carnitine plays a crucial role in metabolism and inflammatory responses. Carnitine may be important in improving neuronal dysfunction and loss of neurons.
To evaluate serum carnitine concentration in adult patients with various clinical types of LB.
Groups: 1) patients with erythema migrans (EM, n=16), 2) neuroborreliosis (NB, n=10), 3) post-Lyme disease (PLD, n=22) and healthy controls (HC, n=32). Total (TC) and free (FC) carnitine were determined with the spectrophotometric method.
TC levels (44.9±10.4, 28.0±8.4, 35.9±15.6 ?mol/L) in the EM, NB and PLD patients were lower than in HC (54.0±11.4 ?mol/L), p < 0.001. FC levels (32.7±7.7, 23.6±6.8, 26.3±11.2 ?mol/L) in the EM, NB and PLD patients were lower than in HC (40.5±7.6 ?mol/L), p < 0.001. AC levels (12.2±5.2, 4.4±2.6, 9.6±7.4 ?mol/L) in the EM, NB and PLD patients were lower in the NB and PLD patients than in HC (13.5±8.40 ?mol/L), p <0.001. AC/FC ratio was 0.31±0.14, 0.18±0.09, 0.39±0.33 in the EM, NB and PLD patients.
LB patients exhibit a significant decrease of their serum carnitine concentrations. The largest changes were in the NB and PLD patients. To prevent late complications of the disease a possibility of early supplementation with carnitine should be considered. Further studies are required to explain the pathophysiological significance of our findings.
Source: By Kepka A1, Pancewicz SA2, Janas RM1, Swierzbinska R2. Serum carnitine concentration is decreased in patients with Lyme borreliosis. Postepy Hig Med Dosw (Online). 2016 Mar 4;70:180-5. doi: 10.5604/17322693.1196388.