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CD8+ T cells are activated during the early Th1 and Th2 immune responses in a murine Lyme disease model.

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Abstract

T-helper responses following Borrelia burgdorferi infection in mice determine susceptibility to
Lyme arthritis. The ratio of interleukin 4-positive, CD4+ to gamma interferon (IFN-gamma)-positive, CD4+ T cells was significantly greater in infected BALB/cJ mice than in infected C3H/HeJ mice. Increased numbers of IFN-gamma-producing cells predicted greater arthritis severity, and CD8+ T cells were the main source of IFN-gamma in both strains.

Infect Immun. 1997 Dec;65(12):5334-7. Research Support, Non-U.S. Gov’t; Research Support, U.S. Gov’t, P.H.S.

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