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Cellular immune findings in Lyme disease.

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Abstract

From 1981 through 1983, we did the first testing of cellular immunity in
Lyme disease. Active established
Lyme disease was often associated with lymphopenia, less spontaneous suppressor cell activity than normal, and a heightened response of lymphocytes to phytohemagglutinin and
Lyme spirochetal antigens. Thus, a major feature of the immune response during active
disease seems to be a lessening of suppression, but it is not yet known whether this response plays a role in the pathophysiology of the
disease.

Yale J Biol Med. 1984 Jul-Aug;57(4):595-8. Research Support, Non-U.S. Gov’t; Research Support, U.S. Gov’t, P.H.S.

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