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Central nervous system manifestations of Lyme disease.

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Abstract

We studied six patients with central nervous system manifestations of
Lyme disease. Weeks to years after the initial infection, behavioral changes, ataxia, and/or weakness in bulbar or peripheral muscles developed. Four of the six patients had a lymphocytic pleocytosis in the cerebrospinal fluid, and two of them had magnetic resonance imaging scans suggestive of demyelination. In a patient with a subacute encephalitis, a brain biopsy specimen showed microgliosis without an inflammatory infiltrate and spirochetes morphologically compatible with Borrelia burgdorferi. All six patients had elevated antibody titers to B burgdorferi in serum, but none had selective concentration of specific antibody in the cerebrospinal fluid. All six patients were treated with high-dose intravenous penicillin; four had complete recoveries and two did not.
Lyme disease may affect the central nervous system causing organic brain
disease or syndromes suggestive of demyelination.

Arch Neurol. 1989 Jul;46(7):790-5. Case Reports; Research Support, U.S. Gov’t, P.H.S.

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