Cerebral dysfunction in fibromyalgia (FM): evidence from regional cerebral blood flow measurements, otoneurological tests & cerebrospinal fluid analysis

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Measurements of regional cerebral blood flow (rCBF), analysis of
cerebrospinal fluid, auditory brain stem responses (ABR) and
oculomotor tests were performed in 19 patients with
fibromyalgia. The results from the rCBF measurements showed a
normal flow level with slight but significant focal flow
decreases in dorsolateral frontal cortical areas of both
hemispheres. The ABR results showed signs of dysfunction at
least at the brain stem level and the oculomotor tests showed
high frequency of pathology. The cerebrospinal fluid analysis
showed discrete changes in the cell differential count.
Possible explanations for the involvement of the central
nervous system in fibromyalgia are discussed.

Johansson G, Risberg J, Rosenhall U, Orndahl G, Svennerholm L,
Nystrom S

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