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All the 18 patients with acrodermatitis chronica atrophicans (ACA) showed the specific borrelia antibody at the indirect immunofluorescence assay. The patients exhibited a large spectrum of arthritic and neurologic complaints besides the typical cutaneous symptoms. Changes of proteins, of liver-typical parameters and of the electrocardiogram are also assigned to the
Lyme-borreliosis. The penicillin therapy – three times accompanied by a Jarisch-Herxheimer-reaction – led to regression of the clinical changes. The secessions of borrelia-antibody-titers happens only very delayed. That is why it can not be used for the direct therapy control. The increased documented polysymptomatic of
Lyme-borreliosis requires a wider knowledge and the country-wide possibility of specific diagnostic.