Chronic Fatigue Syndrome (CFS): a novel disorder with cutaneous manifestations

Persistent and disabling fatigue associated with low-grade fever and

other constitutional symptoms, without any known disorder that

accounts for it, is recognized as chronic fatigue syndrome

(CFS). Skin lesions occur in 10-35% of patients, but their

description is inaccurate. Recurrent aphthous stomatitis or

persistent Epstein-Barr virus (EBV)-related erythema

multiforme have also been reported. Patients may be diagnosed

as having CFS only when they fulfill at least 2 major and 8

minor criteria. Major criteria are the presence of

debilitating fatigue persisting or recurring for at least 6

months and the absence of any other medical disorder that may

explain it. Although different viral or nonviral etiologies

have been documented, evidence implicating EBV is gaining


Rebora A, Drago F

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