Chronic Fatigue Syndrome (CFS) – a public health concern

Chronic fatigue syndrome (CFS) has emerged as a public health
concern over the past decade. A working case definition was
created in 1988 and revised in 1994, and this has been used
to establish prevalence estimates using physician-based
surveillance and an a random digit dial telephone survey.

Although CFS has some characteristics of an infectious
disease, so far no infectious agent has been associated with
the illness. Studies of immune function in CFS patients
failed to detect differences between cases and healthy
controls. However, when cases were subgrouped according to
whether they had a sudden or gradual onset, differences in
immunologic markers were detected between cases and their
matched controls.

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