OBJECTIVE: To describe clinical and laboratory guidelines for
assessment and management of patients presenting with chronic
fatigue syndrome (CFS).
DATA SOURCES: Relevant international
consensus diagnostic criteria and research literature on the
epidemiology, pathophysiology, concurrent medical and
psychological disturbance and clinical management of CFS.
CONCLUSIONS: Medical and psychiatric morbidity should be
carefully assessed and actively treated, while unnecessary
laboratory investigations and extravagant treatment regimens
should be avoided. No single infective agent has been
demonstrated as the cause of CFS, and immunopathological
hypotheses remain speculative. The aetiological role of
psychological factors is debated, but they do predict
prolonged illness. The rate of spontaneous recovery appears to
be high. Effective clinical management requires a
multidisciplinary approach, with consideration of the medical,
psychological and social factors influencing recovery.
[References: 48] EM- 9601
Hickie IB, Lloyd AR, Wakefield D