Chronic Fatigue Syndrome (CFS) update. Findings now point to CNS involvement

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Neither Epstein-Barr virus nor human herpesvirus 6 appears to play a
causative role in chronic fatigue syndrome. The possibility
that a novel human retrovirus may be present in patients with
the syndrome needs further study. A number of abnormalities
found in patients with chronic fatigue syndrome point to
central nervous system (CNS) involvement. These include
immunologic abnormalities, indications of pituitary and
hypothalamic involvement, abnormal basal plasma levels of
certain neurotransmitter metabolites, and cerebral perfusion
abnormalities. The symptom pattern of chronic fatigue syndrome
may eventually be explainable in terms of CNS dysfunction.

Bell DS

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