Cardiovascular and autonomic dysfunction have been suggested to underly the symptoms accompanying CFS (chronic fatigue syndrome). In the [June 2009] issue of Clinical Science, Hurwitz and colleagues have investigated:
• Whether deficits were present in cardiac output and blood volume in a cohort of patients with CFS
• And whether these were linked to illness severity and sedentary lifestyle.
The results clearly demonstrated:
• Reduced cardiac stroke volume and cardiac output in more severely afflicted patients with CFS,
• Which is primarily attributable to a measurable reduction in blood volume.
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Similar findings are observed:
• In microgravity and bedrest deconditioning,
• In forms of orthostatic intolerance,
• And to a lesser extent in sedentary people.
The circulatory consequences of reduced cardiac output may help to account for many of the findings of the syndrome.
Source: Clinical Science (London), Jun 18, 2009. PMID: 19534728, by Stewart JM. Pediatrics and Physiology, New York Medical College, Hawthone, New York, USA. [E-mail: firstname.lastname@example.org]
[Note: See also Hurwitz, BE, Klimas NG, et al. "Chronic Fatigue Syndrome: Illness severity, sedentary lifestyle, blood volume and evidence of diminished cardiac function," Clinical Science, May 26, 2009.]