A DGReview of :"Cytokines in nasal lavage fluids from acute sinusitis, allergic rhinitis, and chronic fatigue syndrome subjects." Allergy and Asthma Proceedings.
By Elda Hauschildt
It is unlikely that rhinitis in chronic fatigue syndrome (CFS) has an inflammatory component.
United States researchers found no differences between CFS and non-CFS subjects when they compared degrees of inflammation in 13 acute sinusitis patients, 16 active allergic rhinitis patients, 95 CFS patients and 89 non-CFS controls.
Cytokine concentrations in nasal lavage fluids were measured. Measurements included concentrations of total protein, nerve growth factor (NGF), tumour necrosis factor (TNF) alpha and interleukin (IL)-8.
Investigators from Georgetown University in Washington, DC, subdivided the CFS and non-CFS groups using allergy skin test and rhinitis score results.
They report acute sinusitis patients had significantly higher total protein, TNF-alpha and IL-8 concentrations and IL-8/total protein ratios in comparison to patients in the other three study groups.
No differences were observed based on skin test or rhinitis score severity within the CFS and non-CFS groups.
The researchers also note the mucopurulent discharge of acute sinusitis patients contained significantly higher TNF-alpha and IL-8. They suggest neutrophils as a likely source for these cytokines.
Allergy and Asthma Proceedings, 2002; 23: 185-190. "Cytokines in nasal lavage fluids from acute sinusitis, allergic rhinitis, and chronic fatigue syndrome subjects."