Chronic parvovirus B19 infection resulting in Chronic Fatigue Syndrome (CFS): case history & review

The spectrum of disease caused by parvovirus B19 has been expanding
in recent years because of improved and more sensitive methods
of detection. There is evidence to suggest that chronic
infection occurs in patients who are not detectably
immunosuppressed. We report the case of a young woman with
recurrent fever and a syndrome indistinguishable from chronic
fatigue syndrome. After extensive investigation, we found
persistent parvovirus B19 viremia, which was detectable by
polymerase chain reaction (PCR) despite the presence of IgM
and IgG antibodies to parvovirus B19. Testing of samples from
this patient suggested that in some low viremic states
parvovirus B19 DNA is detectable by nested PCR in plasma but
not in serum. The patient's fever resolved with the
administration of intravenous immunoglobulin.

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