Chronic urticaria [hives] is usually associated with fibromyalgia syndrome – Source: Acta Dermato Venereologica, Aug 2009

Although the pathophysiology of chronic urticaria [hives] is not fully understood, it is possible that dysfunctioning of peripheral cutaneous nerve fibers may be involved. It has also been suggested that fibromyalgia syndrome, a multi-symptomatic chronic pain condition, may be associated with alterations and dysfunctioning of peripheral cutaneous nerve fibers [in the skin].

The aim of this study was to determine whether patients with chronic urticaria are also affected by fibromyalgia syndrome.

A total of 126 patients with chronic urticaria were investigated for fibromyalgia syndrome. An unexpectedly high proportion (over 70%) had fibromyalgia syndrome.

The corresponding proportion for 50 control dermatological patients [having FM] was 16%, which is higher than previously published data for the Italian general population (2.2%).

It is possible that dysfunctional cutaneous nerve fibers of patients with fibromyalgia syndrome may release neuropeptides, which, in turn, may induce dermal microvessel dilatation and plasma extravasation.

Furthermore, some neuropeptides may favor mast cell degranulation, which stimulates nerve endings, thus providing positive feedback.

Chronic urticaria may thus be viewed in many patients as a consequence of fibromyalgia syndrome; in fact, skin neuropathy (fibromyalgia syndrome) may trigger neurogenic skin inflammation (chronic urticaria).

Source: Acta Dermato Venereologica, Aug 2009;89(4):389-92. PMID: 19688152, by Torresani C, Bellafiore S, De Panfilis G. Section of Dermatology, Department of Surgical Sciences, University of Parma, Italy. [E-mail:]

1 Star2 Stars3 Stars4 Stars5 Stars (50 votes, average: 3.50 out of 5)

2 thoughts on “Chronic urticaria [hives] is usually associated with fibromyalgia syndrome – Source: Acta Dermato Venereologica, Aug 2009”

  1. nansowl says:

    I never would have thought of connecting the hives I get when it gets too warm (for me) with fibromyalgia. Just when I think I’ve got this crazy disease figured out it throws me another curve. Interesting connection.

  2. mamacitabonita says:

    I started braking out in hives in May. I have had Fibromyalgia for twenty years so I did not make the connection between the hives and fibromyalgia. I just thought something else was going on. I have gone through 8 tubes of lanacaine in four months and am going to get tested for alergies. I have done a lot of research on fibromyalgia. Hives is not something I had come across before. I am writing a book on the subject. I guess I just got another chapter!

Leave a Reply