Chronobiological influences on fibromyalgia (FM) syndrome: theoretical & therapeutic implications

A review of the evidence from diurnal physiological, seasonal

environmental and prospective studies of social-behavioural

functions suggest that a chronobiological theoretical model

provides a comprehensive basis for the dynamics of central

nervous system mechanisms, the assessment and the management

of patients with fibromyalgia. The chronobiological model

stresses the importance of temporal variation and the factors

that influence and govern recurrent patterns of biological

functions and behaviour that determine health and illness.

Finally, the theory allows for an integrated study of brain,

behaviour and somatic functions over time and emphasizes that

such a comprehensive approach is core to any therapeutic


Moldofsky H

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