Clinical Correlate of Brain SPECT Perfusion Abnormalities in Fibromyalgia – Source: Journal of Nuclear Medicine, Oct 16, 2008

The purpose of this study was to investigate the specific clinical correlate of brain SPECT perfusion abnormalities reported in fibromyalgia. [SPECT (single photon emission computed tomography) provides multiple 2-D images from multiple angles that can provide a 3-D image. In this case it was used to evaluate blood flow (perfusion) to regions of the brain.]

Methods: We performed a whole-brain voxel-based correlation analysis involving regional cerebral blood flow and various parameters related to:

• Pain (Visual Analog Scale, Tubingen Pain Behavior Scale, and Questionnaire Douleur de Saint-Antoine Scale),

• Disability (Fibromyalgia Impact Questionnaire [FIQ]) [the higher the total FIQ score, the greater the impact FM is having on the patient’s life],

• And anxiety and depression status (Hospital Anxiety and Depression scale)…

… in 20 patients with fibromyalgia (P voxel < 0.005).

Ten healthy control women were also included, in order to determine areas of significant hypo- and hyperperfusions in patients [less than and greater than in healthy controls, respectively].

Results: FIQ total score was positively correlated with bilateral parietal perfusion, including postcentral cortex. These clusters of correlation were included in the areas of significant hyperperfusion.

FIQ total score was also negatively correlated with perfusion of a left anterior temporal cluster, included in the areas of significant hypoperfusions. No other clinical correlation was observed with regional cerebral blood flow.

Conclusions: These results show that brain perfusion abnormalities in patients with fibromyalgia are correlated with the clinical severity of the disease.

Source: Journal of Nuclear Medicine, Oct 16, 2008. E-pub ahead of print. PMID: 18927329, by Guedj E, Cammilleri S, Niboyet J, Dupont P, Vidal E, Dropinski JP, Mundler O. Service Central de Biophysique et de Medecine Nucleaire, AP-HM Timone, Marseille, France. [E-mail: eric.guedj@ap-hm.fr]

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