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Coexposure to Borrelia burgdorferi and Babesia microti does not worsen the long-term outcome of lyme disease.

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Previous studies suggest that concurrent
Lyme disease and babesiosis produce a more sever illness than either
disease alone. The majority of babesiosis infections, however, are subclinical. Our objective was to characterize on the basis of a total-population survey of Nantucket Island, Massachusetts, whether coexposure to
Lyme disease and babesiosis causes more severe illness or poorer long-term outcomes than
Lyme disease alone. In this retrospective cohort study, residents indicating a history of
Lyme disease were compared with randomly selected population controls on a standardized medical history, blinded physical examination, and serological studies for Borrelia burgdorferi and Babesia microti. Serological evidence of exposure to babesiosis was not associated with increased severity of acute
Lyme disease. The groups did not differ with regard to the prevalence of constitutional, musculoskeletal, or neurological symptoms a mean of 6 years after acute
Lyme disease. Prior
Lyme disease and serological exposure to B. microti are not associated with poorer long-term outcomes or more persistent symptoms
Lyme disease alone.

Clin Infect Dis. 2000 Nov;31(5):1149-54. Epub 2000 Nov 6. Research Support, Non-U.S. Gov’t; Research Support, U.S. Gov’t, P.H.S.

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