Cognitive functioning in Chronic Fatigue Syndrome (CFS) & depression: a preliminary comparison

This study used a brief battery of neuropsychological measures

to examine the performance of patients with chronic fatigue

syndrome (CFS) (N = 16) and patients in a major depressive

episode (N = 23). The overall neuropsychological performance

of the CFS group was not significantly different from

depressed patients, and both groups scored within normal

limits on most measures. Variability of neuropsychologic

performance was in general unrelated to level of depressive

symptoms. The results are discussed in terms of the validity

of the cognitive criterion for the CFS diagnosis.

Subjective complaints of cognitive dysfunction by CFS

patients in light of the lack of objective evidence for the

same are considered in terms of a somatic vigilance


Schmaling KB, DiClementi JD, Cullum CM, Jones JF

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