Comparison of 99m Tc HMPAO SPECT scan between Chronic Fatigue Syndrome (CFS), major depression & healthy controls: an exploratory study of clinical correlates of regional cerebral blood flow

An explorative analysis of the relationship between

symptomatology and cerebral blood flow in the chronic fatigue

syndrome (CFS) as assessed with 99mTc HMPAO SPECT scan reveals

statistically significant positive correlations between

frontal blood flow on the one hand and objectively and

subjectively assessed cognitive impairment, self-rating of

physical activity limitations and total score on Hamilton

Depression Rating Scale on the other. A pathophysiological

role of frontal blood flow in the cognitive impairment and

physical activity limitations in CFS is hypothesized. A

comparison of cerebral blood flow between CFS, major

depression (MD) and healthy controls (HC) has been performed.

A lower superofrontal perfusion index is demonstrated in MD as

compared with both CFS and HC. There is neither a global nor a

marked regional hypoperfusion in CFS compared with HC.

Asymmetry (R > L) of tracer uptake at parietotemporal level is

demonstrated in CFS as compared with MD.

Fischler B, D’Haenen H, Cluydts R, Michiels V, Demets K, Bossuyt A,

Kaufman L, De Meirleir K

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