Comparison of SPET [SPECT] brain perfusion & 18F-FDG brain metabolism in patients with Chronic Fatigue Syndrome (CFS)

Chronic fatigue syndrome is a clinically defined condition of
uncertain aetiology. We compared 99Tcm-HMPAO single photon
emission tomography (SPET) brain perfusion with dual-head
18F-FDG brain metabolism in patients with chronic fatigue
syndrome. Eighteen patients (14 females, 4 males), who
fulfilled the diagnostic criteria of the Centers for Disease
Control for chronic fatigue syndrome, were investigated.
Thirteen patients had abnormal SPET brain perfusion scans and
five had normal scans. Fifteen patients had normal glucose
brain metabolism scans and three had abnormal scans. We
conclude that, in chronic fatigue syndrome patients, there is
discordance between SPET brain perfusion and 18F-FDG brain
uptake. It is possible to have brain perfusion abnormalities
without corresponding changes in glucose uptake.

Abu-Judeh HH, Levine S, Kumar M, el-Zeftawy H, Naddaf S, Lou JQ, Abdel-Dayem HM

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