Continuous measurement of BRSI in Chronic Fatigue Syndrome

[Note: The autonomic nervous system makes important contributions to the homeostatic or stabilizing regulation of the heart and blood vessels through arterial baroreflexes. BRSI stands for baroreceptor sensitivity index, a measure of baroreflex function.]

Journal: Conference Proceedings Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2004;2:906-8 [Recently added to National Library of Medicine listing.]

Authors and affiliation: Donnelly D, Rockland RH, Reisman S, Quigley KS. New Jersey Institute of Technology, Newark, New Jersey, USA.

PMID: 17271825

This paper discusses the development of a system to measure continuous cardiac baroreceptor measurement during a 45-minute 70-degree head-up tilt (HUT) of five groups of subjects suffering the following:

n Chronic Fatigue Syndrome (CFS),
n CFS with Fibromyalgia (CFS-FM),
n CFS with postural orthostatic tachycardia syndrome (CFS-POTS),
n Controls with POTS (CON-POTS),
n Controls (CON).

The duration of the test was 56 minutes, which included a five-minute supine baseline, a 45-minute HUT and a six-minute recovery period.

The system was developed in LabView, and can provide a comparative time analyses of weighted BRSI averages. Baroreflex effectiveness index (BEI) was also investigated over the course of lags 0, 1 and 2 as well as an assessment of overall BEI performance between groups.

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