Thirty-four patients with a probable Alzheimer’s Disease (AD) (mild AD = 16; moderate AD = 18) and 12 matched controls were evaluated using semiquantitative SPECT-99mTc-HMPAO and neuropsychological tests (CERAD).
RESULTS: Both temporal hypoperfusion (p < 0.01) and memory tests (p < 0.001) made it possible to differentiate the controls from mild AD patients. In these patients, significant correlations (p < 0.05) were also found between: 1) delayed recall test/temporal hypoperfusion, 2) learning memory test/temporoparietal and frontal hypoperfusion and 3) visual constructive praxis/posterior temporal hypoperfusion. In contrast to mild AD, moderate AD patients showed higher temporal (p < 0.01) parietal and frontal (p < 0.05) hypoperfusion along with worsening of praxis (p < 0.001) and memory tests (p < 0.05).
CONCLUSIONS: SPECT imaging and neuropsychology evaluation can distinguish controls from AD patients with mild and moderate grades of dementia, showing a strong correlation from the early stages of AD.
Source: Rev Esp Med Nucl 1999 Aug;18(4):252-60
PMID: 10481106, UI: 99412512
(Servicio de Medicina Nuclear, Clinica Universitaria de Navarra, Pamplona, Navarra, 31008, Espana.)