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Curcumin, resveratrol, ursolic acid show promise against prostate cancer

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Reprinted with the kind permission of Life Extension.

June 07 2017. An article appearing on June 5, 2017 in the Nature Partners Journal npj Precision Oncology reveals a potential benefit for several plant compounds against prostate cancer.

By screening 142 phytochemicals in a natural compound library and testing varying doses alone or in combination in mouse and human prostate cancer cell lines, researchers at the University of Texas at Austin identified curcumin from turmeric, resveratrol, found in red grapes and other plants, and ursolic acid, which occurs in rosemary and apple peel as having anticancer effects. 

The three compounds were subsequently evaluated alone or in combination in mice that had received implanted prostate tumor cells. Tumor volume was monitored beginning on the first day of treatment with the compounds and continued through the thirty-second day. It was found that curcumin or ursolic acid had the greatest anticancer effects, and that ursolic acid also boosted the effects of curcumin or resveratrol. “The in vivo studies provided further evidence that the selected natural compound combinations were highly effective in slowing growth of murine prostate cancer cells,” authors Alessia Lodi and colleagues report.

“After screening a natural compound library, we developed an unbiased look at combinations of nutrients that have a better effect on prostate cancer than existing drugs,” commented corresponding author Stefano Tiziani, who is an assistant professor in the Department of Nutritional Sciences and Dell Pediatric Research Institute at the University of Texas Austin. “The beauty of this study is that we were able to inhibit tumor growth in mice without toxicity.”
“These nutrients have potential anticancer properties and are readily available,” he added. “We only need to increase concentration beyond levels found in a healthy diet for an effect on prostate cancer cells.”

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