Current concepts in the pathophysiology of abnormal pain perception in fibromyalgia (FM)

Fibromyalgia is a noninflammatory rheumatic disorder characterized

by chronic widespread musculoskeletal pain. Although many

studies have described the pain and other clinical symptoms

associated with this disorder, the primary mechanisms

underlying the etiology of fibromyalgia remain elusive. This

article reviews recent data supporting the links among each of

three systems–the musculoskeletal system, the neuroendocrine

system, and the central nervous system (CNS), all of which

appear to play major roles in fibromyalgia

pathophysiology–and pain in fibromyalgia, and concludes by

presenting a model of the pathophysiology of abnormal pain

perception in fibromyalgia which integrates the research

findings described.

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