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Cytotoxic mechanisms may play a role in the local immune response in the central nervous system in neuroborreliosis.

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Abstract

Aiming to investigate the role of cytotoxic mechanisms in neuroborreliosis (NB), the cytokines IL-2, IL-7, IL-10, IL-12p70, IL-15, GM-CSF and the Th17-cytokine IL-17 were analyzed in cerebrospinal fluid (CSF) and plasma from NB-patients. NB-patients showed increased levels in CSF compared to controls of all analyzed cytokines except IL-15 but not in plasma. Blood lymphocytes from three NB-patients showed functional cytotoxicity in response to autologous Borrelia-infected macrophages. The findings support a role for cytotoxic mechanisms in the local immune response in NB and in addition suggest an increase of IL-17.

Copyright © 2010 Elsevier B.V. All rights reserved.

J Neuroimmunol. 2011 Mar;232(1-2):186-93. doi: 10.1016/j.jneuroim.2010.09.028. Epub 2010 Nov 5. Research Support, Non-U.S. Gov’t

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