Daily ingestion of a nutritional probiotic supplement enhances innate immune function in healthy adults

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Journal: Nutrition Research. Volume 26, Issue 9, September 2006, Pages 454-459. [Available online September 30] Authors and affiliations: Sheryl H. Berman, Petra Eichelsdoerfer, Daesong Yim, Gary W. Wlmer, Cynthia A. Wenner. Department of Basic Sciences, School of Natural Health Sciences, Bastyr University, Kenmore, Washington (Berman, Eichelsdoerfer, Yim, Wenner); and Department of Medicinal Chemistry, University of Washington School of Phramacy, Seattle, Washington (Elmer), USA. [E-Mail: sberman@bastyr.edu] DOI: 10.1016/j.nutres.2006.08.002

In this pilot study (n = 10), we investigated whether daily ingestion of a delayed release 4-species probiotic supplement over an 8-week period would enhance innate immune function in a nonelderly adult population.

The parameters of innate immunity assessed were natural killer cell activity, phagocytic activity, and salivary secretory immunoglobulin A. A 1-arm intervention trial was performed in which 10 volunteers served as their own controls. Immune parameters were measured at baseline and during treatment at 3, 5, and 8 weeks.

A statistically significant increase in the percentage of phagocytic monocytes (P = .0005) and neutrophils (P = .0122) occurred over the 8-week treatment period. No statistically significant increases of natural killer cell activity or salivary immunoglobulin A levels were observed.

In conclusion, nutritional supplementation with probiotics has the potential to improve innate immune function in healthy adults.

Keywords: Probiotics; Lactobacillus; Bifidobacteria; Intestinal flora; Gut flora; Immune system; Monocyte function; Neutrophil function; Phagocytosis; NK cell activity; Salivary IgA; Secretory IgA

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