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Dehydroepiandrosterone sulfate deficiency in Chronic Fatigue Syndrome (CFS)

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The chronic fatigue syndrome (CFS) is a condition of unknown
etiology, characterized by a persistent debilitating fatigue,
the muscle-related symptoms and the neuropsychiatric symptoms.

Recently, it has been reported that the patients with CFS might
have impaired activation of the hypothalamic-pituitary-adrenal axis,
and suggested that a part of the patho-genesis of CFS might be
associated with abnormalities of the endocrine system. Herein, we
show that the majority of Japanese patients with CFS had a serum
dehydroepiandrosterone sulfate (DHEA-S) deficiency. Serum
DHEA-S is one of the most abundantly produced hormones which
is secreted from the adrenal glands, and its physiological
function is thought to be a precursor of sex steroids. DHEA-S
has recently been shown to have physiological properties, such
as neurosteroids, which are associated with such
psychophysiological phenomena as memory, stress, anxiety,
sleep and depression. Therefore, the deficiency of DHEA-S
might be related to the neuropsychiatric symptoms in patients
with CFS.

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Differences in adrenal steroid profile in Chronic Fatigue Syndrome (CFS), in depression & in health
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