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Development of autoimmunity in Lyme arthritis.

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Abstract

Treatment-resistant
Lyme arthritis (TRLA) develops in 10% of
Lyme arthritis patients and is characterized by continuous joint inflammation that does not resolve with antibiotic therapy. TRLA is associated with HLA-DRB1*0401 and related alleles, as well as with an immune response to the Borrelia burgdorferi (Bb) outer surface protein A (OspA). The immunodominant epitope of OspA in the context of HLA-DRB1*0401 corresponds to amino acids 165-173 (OspA165-173). The human Lymphocyte Function Antigen-1 (hLFA1alpha) contains a peptide with homology to OspA165-173. Treatment-resistant
Lyme arthritis patients’ T cells, cloned based on their ability to bind OspA165-173-loaded HLA-DRB1*0401 tetramers, respond to OspA and hLFA1alpha with a different cytokine profile, suggesting that hLFA1alpha acts as a partial agonist with a potential role in the perpetuation of joint inflammation.

Curr Opin Rheumatol. 2002 Jul;14(4):388-93. Research Support, Non-U.S. Gov’t; Research Support, U.S. Gov’t, P.H.S.; Review

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