Diazinon-induced brain toxicity and protection by vitamins E plus C – Source: Toxicology and Industrial Health, May 4, 2011

[Note: The once-lavishly employed flea & insect killer diazenon is an example of an organophosphate that is highly toxic to the human nervous system.]

Diazinon (DI) is a widely used pesticide in agriculture, resulting in environmental deleterious effects on neural systems.

The current study was performed to investigate the effects of treatment with vitamins E plus C on brain toxicity, which is possibly induced by Diazinon.

Twenty-one male rats were divided into three groups (n = 7 per group) as follows:
1. Control group (C);
2. Diazinon-treated group (DI);
3. Diazinon + vitamins E and C-treated group (DI + Vitamins).

In order to examine lipid peroxidation [free radical destruction of lipids making up cell membranes] and antioxidant [free-radical defense] status in rats, the level of malondialdehyde (MDA), activities of two free radical scavenging enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) have been studied in brain of rat.

The results showed that:

• Treatment with diazinon induced significant (p < 0.05) increases in the level of serum malondialdehyde in rat brain. [Malondialdehyde is a marker for oxidative stress.]

• The vitamins E plus C combination reduced lipid peroxidation in rat brain. The activity of SOD level was significantly higher in DI + Vitamins group, compared to the control group.

• GSH-Px, SOD and CAT values were not significantly different in the Diazinon-treated group than in the control group.

Oxidative stress contributes to Diazinon-induced brain toxicity. Our results suggested that vitamins E plus C combination may have a protective effect on Diazinon-induced brain toxicity.

Source: Toxicology and Industrial Health, May 4, 2011. Yilmaz N, Yilmaz M, Altuntas I. Department of Biochemistry, Mustafa Kemal University Medical School and Department of Neurology, Antakya State Hospital, Hatay; Department of Biochemistry, Suleyman Demirel University Medical School, Isparta, Turkey. [Email: drniaratilgan@yahoo.com]

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