Dietary Intervention in Chronic Fatigue Syndrome – Source: Journal of Human Nutrition and Dietetics, April 2008

Background: Anecdotal reports and books have been published linking an over growth of Candida Albicans (yeast) with Chronic Fatigue Syndrome (CFS), suggesting dietary change as a treatment option. Little scientific data has been published to validate this controversial theory. This study aims to determine the efficacy of dietary intervention on level of fatigue and quality of life (QoL) in individuals with CFS.

Methods: A 24-week randomized intervention study was conducted with 52 individuals diagnosed with CFS. Patients were randomized to either a low sugar low yeast (LSLY) or healthy eating (HE) dietary interventions. Primary outcome measures were fatigue as measured by the Chalder Fatigue Score and QoL measured by Medical Outcomes Survey Short Form-36.

Results: A high drop-out rate occurred, with 13 participants not completing the final evaluation (7HE/6LSLY). Intention to treat analysis showed no statistically significant differences on primary outcome measurements.

Conclusion: In this randomized control trial, a low sugar low yeast diet appeared to be no more efficacious on levels of fatigue or QoL compared to healthy eating.

Given the difficulty with dietary compliance experienced by participants, especially in the low sugar low yeast group, it would appear healthy eating guidance is a more pragmatic approach than advocating a complicated dietary regime.

Source: Journal of Human Nutrition and Dietetics, April 2008. 21 (2), 141-149. [E-pub ahead of print] DOI:10.1111/j.1365-277X.2008.00857.x , by Hobday RA, Thomas S, O'Donovan A, Murphy M, Pinching AJ. Infection and Immunity Speciality Group, St. Bartholomew's Hospital, West Smithfield, London, UK. [E-mail:]

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5 thoughts on “Dietary Intervention in Chronic Fatigue Syndrome – Source: Journal of Human Nutrition and Dietetics, April 2008”

  1. moker says:

    I have had CFS for three years and took part in a LSLY diet after being diagnosed with servere candida overgrowth (candidasis). After a batch of anti fungal supplements (no drugs but natural treatments such as caprylic acid) and some high quality probiotics(Biocare acidopholus) accompanying the diet, my heath inporved 80%. I have not felt so good since developing CFS.

    Maybe my heavy antibiotic use for a year helped the candida overgrowth, but it really has been benifical. I think it’s dangerous to ignore such anicodtal evidence with studies such as this – and obviously healthy eating helps also.


    1. nerg says:

      I have been diagnosed with Chronic Fatigue and with severe candida as well. My Dr. has me on Nystatin and a probiotic. The diet is very hard for me to follow. I do really well for a couple days and then when I run out of food that we made specially for me, I eat crummy again. I am worried that I keep going through the stages of overgrowth diedown, which makes you a bit ill at first. Anyway, my question for you is what is caprylic acid? Did you try that Threelac product I see advertised? How are you eating now and would you say your candida is gone?

    2. moker says:

      My candida is effectively gone yes. My massive sensitivity to alcohol has reduced (I had two drinks – The first time I’ve touched alcohol in 10 months last week), as has my more severe symptoms such as brain fog, fatigue, flu like symptoms, heart skips are to a minimum etc. It didn’t help my chest pain or muscle / tendom pain and but that’s a CFS issue…

      I read Leon Chaitow’s book Candida Albicans: The Non-drug Approach to the Treatment of Candida Infection and happened to also meet with an old friend who had gone through the same thing about a year before – So I got loads of excellent advice.

      Also, the clinic I went to (don’t know where you live but it was in London) gave me a superb all-in-one natural anti fungal mix called “Caprylic Plus” – It contained caprylic acid, cinnamon, slippery elm, peppermint, everything really. I took those with a LSLY diet for a month. Had a month off (but kept the diet in place) then did it again for two months, including taking the 24 billion culture probiotics as mentioned above.

      Although I’m slowly introducing sugar and yeast again, I’m now taking aloe vera (anti fungal) once a day, as well as a barley grass drink in the mornings. It’s a slow step down off the programme and I didn’t even try the more potent anti fungal herbs such as wild oregano oil.

      If I were you, I’d buy Leon Chaitow’s book. It is very useful indeed, concise and will really open your eyes. It was like reading a book about myself. The diet is restrictive as hell, but I survived by being prepared and enjoyinh eating things that I could – Roast dinners, rice dishes, rye breads, eggs, organic meats etc.

      I’d try this programme for three months without “cheating” as it is tremendous and drug free!

    3. jid says:

      Complicated dietry regime??? What could be complicated about “Don’t eat sugar!” It has helped me immensely.

      1. MIssAutumn says:

        And I agree,it really isn’t that complicated, and has helped me immensely, too!!!!

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