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Discriminating Lyme neuroborreliosis from other neuroinflammatory diseases by levels of CXCL13 in cerebrospinal fluid.


CXCL13 in cerebrospinal fluid (CSF) could be an important component for diagnosing
Lyme neuroborreliosis (LNB). Levels of intrathecal CXCL13 were determined for 58 LNB patients and 210 controls; sensitivity was 88% and specificity was 89% (cutoff, 250 pg of CXCL13/ml of CSF). Elevated levels of CXCL13 can aid in the diagnosis of LNB, but levels should be interpreted with care.

J Clin Microbiol. 2011 May;49(5):2027-30. doi: 10.1128/JCM.00084-11. Epub 2011 Mar 2. Evaluation Studies [1]