Disordered growth hormone secretion in fibromyalgia (FM): a review of recent findings & a hypothesized etiology

Growth hormone (GH) deficiency occurs in about 30% of
fibromyalgia patients. Treatment of GH deficient fibromyalgia
patients with recombinant growth hormone improves several
clinical features, including the tender point count. Defective
GH secretion in these patients appears to be due to increased
somatostatin tone in the hypothalamus. An hypothesis is
presented which relates dysfunctional GH secretion to the
effects of intermittent hypercortisolemia on upregulating the
density of beta-adrenergic receptors in the hypothalamus. The
resulting augmentation of beta-adrenergic tone stimulates the
release of somatostatin, thus, impairing GH secretion.

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