Diurnal variation of adrenocortical activity in Chronic Fatigue Syndrome (CFS)

Baseline morning and evening serum cortisol and ACTH concentrations,

and diurnal changes in hormone levels, were measured in 30

patients with chronic fatigue syndrome (CFS) but without

concurrent depressive disorder and a control group of 15

weight-, age- and sex-matched healthy volunteers. Morning

cortisol levels were non-significantly lower in CFS patients,

while evening levels were non-significantly higher. ACTH

concentrations were non-significantly higher in both the

morning and evening. The diurnal change in cortisol levels was

significantly less in CFS than in controls (p < 0.05). In CFS

subjects, evening levels of cortisol correlated significantly

with measures of general health and physical functioning,

while diurnal change in cortisol was positively correlated

with measures of functional improvement over the past year and

current social functioning. These results suggest that there

is a relationship between adrenocortical function and

disability in CFS, but do not reveal the causal connection.

1 Star2 Stars3 Stars4 Stars5 Stars (56 votes, average: 2.95 out of 5)

Leave a Reply