Effect of antioxidants combined to resistance training on BMD [bone mineral density] in elderly women: A pilot study – Source: Osteoporosis International, Nov 20, 2008

Summary: We determined the effect of antioxidants and resistance training on bone mineral density of postmenopausal women. After 6 months, we observed a significant decrease in the lumbar spine BMD [bone mineral density] of the placebo group [who received fake supplements and did not do resistance training] while other groups remained stable. Antioxidants may offer protection against bone loss [equal to] resistance training.

Introduction: The purpose of this pilot study was to determine the effects of antioxidant supplements combined [with] resistance training on bone mineral density (BMD) in healthy elderly women.

Methods: Thirty-four postmenopausal women (66.1 +/- 3.3 years) were randomized in four groups (placebo, n = 7; antioxidants, n = 8; exercise and placebo, n = 11; and exercise and antioxidants, n = 8).

The 6-month intervention consisted in antioxidant supplements (600 mg vitamin E and 1,000 mg vitamin C daily) or resistance exercise (3x/week). Femoral neck and lumbar spine BMD (DXA) and dietary intakes (3-day food record) were measured before and after the intervention. A repeated measure ANOVA and non-parametric Mann-Whitney U tests were used.

Results: We observed a significant decrease in the placebo group for lumbar spine BMD (pre, 1.01 +/- 0.17 g/cm(2); post, 1.00 +/- 0.16 g/cm(2); P < 0.05 respectively) while it remained stable in all other groups. No changes were observed for femoral neck BMD. Conclusions:

• Antioxidant vitamins may offer some protection against bone loss in the same extent as resistance exercise,

• Although combining both does not seem to produce additional effects.

Our results suggest to further investigate the impact of antioxidant supplements on the prevention of osteoporosis.

Source: Osteoporosis International, Nov 20, 2008. E-pub ahead of print. PMID: 19020919, by Chuin A, Labonté M, Tessier D, Khalil A, Bobeuf F, Doyon CY, Rieth N, Dionne IJ. Research Centre on Aging, Sherbrooke Geriatric University Institute, Quebec, Canada; Faculty of Sciences and Technical of Sport and Physical Activities, Universite d’Orleans, France; University de Sherbrooke, Quebec, Canada. [Email: Isabelle.Dionne@USherbrooke.ca]

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