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Effects of an Oral Administration of Glucosamine-Chondroitin-Quercetin Glucoside on the Synovial Fluid Properties in Patients with Osteoarthritis and Rheumatoid Arthritis – Source: Bioscience, Biotechnology, and Biochemistry, Online Feb 7, 2009

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[Note: to read the full text of this article free, click here and select “PDF.” Synovial fluid is thick, stringy fluid that cushions and transports nutrients/oxygen to the joint tissues. Quercetin is an anti-oxidant compound found in plants such as green tea, apples.]

In this study, 46 OA and 22 RA patients were administered with the GCQG supplement orally for 3 months. Several parameters of the knee joints were monitored before and after supplementation.

The OA patients showed:

• A significant improvement in pain symptoms, daily activities (walking and climbing up and down stairs), and visual analogue scale,

• And changes in the synovial fluid properties with respect to the protein concentration, molecular size of hyaluronic acid, and chondroitin 6-sulphate concentration were also observed.

However, no such effects were observed in the RA patients. [Though the authors found only “mild” benefits in these patients, but speculate that owing to the greater inflammation with RA, longer term studies may identify greater benefits.]

These results suggest that the GCQG supplement exerted a special effect on improving the synovial fluid properties in OA patients.

Source: Bioscience, Biotechnology, and Biochemistry, Online Feb 7, 2009 [E-pub ahead of print]; 73, 80418-1-5. PMID: 19202302, by Matsuno H, Nakamura H, Katayama K, Hayashi S, Kano S, Yudoh K, Kiso Y. Matsuno Clinic for Rheumatic Diseases, Japan.

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