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Effects of magnesium, high energy phosphates, piracetam & thiamin on erythrocyte transketolase

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Erythrocyte transketolase activity coefficient (ETK-AC) and affinity

for coenzyme (Km TPP) were assessed in 50 patients with

transketolase abnormalities such as fibromyalgia or senile

dementia of Alzheimer’s type, before and after magnesium (Mg),

thiamin+pyridoxine (B1,B6), high energy phosphates (HEP)

(phosphocreatinine of adenosine triphosphate), and piracetam.

Compared to 12 untreated patients, ETK-AC was significantly

decreased with B1,B6 (P < 0.05, n = 10); Km-TPP was

significantly decreased with HEP (P < 0.05, n = 20) and

piracetam (P < 0.01, n = 5). In nine other patients treated

with HEP + B1,B6 + magnesium, ETK-AC and Km TPP were both

significantly decreased.

Eisinger J, Bagneres D, Arroyo P, Plantamura A, Ayavou T

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