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Efficacy of an evernimicin (SCH27899) in vitro and in an animal model of Lyme disease.

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Abstract

The MICs of evernimicin at which 90% of Borrelia burgdorferi patient isolates were inhibited ranged from 0.1 to 0.5 microg/ml. Evernimicin was as effective as ceftriaxone against B. burgdorferi in a murine model of experimental
Lyme disease. As assessed by culturing the urinary bladders of infected C3H mice, no live Borrelia isolates were recoverable following antibiotic treatment.

Antimicrob Agents Chemother. 2001 Mar;45(3):936-7. Research Support, Non-U.S. Gov’t

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