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Efficacy of short-course ceftriaxone therapy for Borrelia burgdorferi infection in C3H mice.

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Abstract

Ceftriaxone is highly effective clinically in patients with
Lyme disease. We studied a representative invasive human isolate of Borrelia burgdorferi for which the MBC of ceftriaxone was 0.050 microg/ml. A once-per-day dosage regimen of ceftriaxone (50 mg/kg/dose) administered intramuscularly for 5 days was 100% effective in sterilizing tissue samples of C3H mice infected with this strain of B. burgdorferi, regardless of whether the mice were being treated concomitantly with a corticosteroid. Administration of the same five doses of ceftriaxone at 6-h intervals over just 24 h was also 100% effective. These experiments suggest that shorter courses of antibiotics than those currently recommended should be considered for study in patients with early uncomplicated
Lyme disease.

Antimicrob Agents Chemother. 2002 Jan;46(1):132-4.

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