Eicosanoids & essential fatty acid modulation in chronic disease & the Chronic Fatigue Syndrome (CFS)

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Abnormalities of Essential Fatty Acid (EFA) incorporation into

phospholipid are found in chronic diseases. More recently

changes in circulating EFA metabolites (EFAM) together with

EFAM hypo-responsiveness of immune cells and EFAM production

from cells have been found associated with disease. We

hypothesize that changes in ratio of EFAMs are the normal

physiological responses to stressors, but when stressors are

excessive or prolonged, EFAM systems may become unpredictably

hypo-responsive owing to factors such as receptor down

regulation and substrate depletion. In time, many homeostatic

system become deranged and held in that state by minor

stressors. Literature review of chronic fatigue syndrome (CFS)

shows hyper and hypo-responsiveness in immune function,

several Hypothalamo-Pituitary (HP) axes and sympathetic

nervous system, all relatable to dysfunctional changes in EFA

metabolism. For the first time, we explain chronic immune

system activation and hypo-responsive immune function in CFS;

through EFAMs. Dietary EFA modulation (DEFA) can alter ratios

of both membrane EFAs and produced EFAMs, and if maintained

can restore hypo-responsive function. We discuss dietary

strategies and relevance in CFS, and a case series of CFS

patients applying DEFA with other titrated published

managements which saw 90% gaining improvement within 3 months

and more than 2/3 fit for full time duties. This hypothesis

and DEFA may have relevance in other chronic conditions.

Gray JB, Martinovic AM

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