Electron microscopic immunocytological profiles in Chronic Fatigue Syndrome (CFS)

Structures consistent in size, shape and character with various
stages of a Lentivirus replicative cycle were observed by
electron microscopy in 12-day peripheral-blood lymphocyte
cultures from 10 of 17 Chronic Fatigue Syndrome patients and
not in controls. Attempts to identify a lymphoid phenotype
containing these structures by immunogold labelling failed and
the results of reverse-transcriptase assay of culture
supernatants were equivocal. The study was blind and
case-controlled, patients being paired with age, sex and
ethnically matched healthy volunteers. Prescreening of
subjects included the common metabolic and immunological
disorders, functional conditions and a virus-screen against
hepatitis B and C, Epstein-Barr Virus, Cytomegalovirus and
Human Immunodeficiency Virus.

MCM: From 1994 AACFS meeting in Ft. Lauderdale

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