OBJECTIVE. To measure, and seek clinical correlates with,
levels of substance P (SP) in the cerebrospinal fluid (CSF) of
fibromyalgia syndrome (FMS) patients.
METHODS. CSF from 32 FMS
patients and 30 normal control subjects was tested for SP by
radioimmunoassay. Clinical measures included tender point
examination and standardized questionnaires.
RESULTS. CSF SP
levels were 3-fold higher in FMS patients than in normal
controls (P < 0.001), but they correlated only weakly with
tenderness found on examination.
CONCLUSION. SP is significantly elevated in FMS CSF, but
other abnormalities must exist in FMS to more fully explain
Russell IJ, Orr MD, Littman B, Vipraio GA, Alboukrek D, Michalek JE,
Lopez Y, MacKillip F