OBJECTIVE: To evaluate serum levels of hyaluronic acid (HA) in
patients with fibromyalgia (FM).
METHODS: HA serum levels were
evaluated by a radiometric assay in 42 women with FM (ACR
criteria), 27 female patients with rheumatoid arthritis (RA)
and 36 healthy female controls matched for age.
serum levels (mean microg/l +/- SEM) were 41 +/- 8.7 in
healthy controls; 113 +/- 15.9 in RA: and 420 +/- 26 in FM.
CONCLUSION: HA serum levels in women with FM were
significantly elevated compared to healthy controls and
patients with RA. This observation suggests that FM is
associated with a biochemical abnormality and that serum HA
could be a laboratory marker for its diagnosis.