Patients with CFS had significantly higher levels of
bioactive TGF-beta levels compared to the healthy control
major depression, SLE, R/R MS, and CP MS groups (P < 0.01).
Additionally, no significant differences were found between
the healthy control subjects and any of the disease
comparison groups. The current finding that TGF-beta is
significantly elevated among patients with CFS supports the
findings of two previous studies examining smaller numbers of
CFS patients. In conclusion, TGF-beta levels were
significantly higher in CFS patients compared to patients
with various diseases known to be associated with immunologic
abnormalities and/or pathologic fatigue. These findings raise
interesting questions about the possible role of TGF-beta in
the pathogenesis of CFS.
Bennett AL, Chao CC, Hu S, Buchwald D, Fagioli LR, Schur PH, Peterson PK, Komaroff AL